Adipokines protecting CKD

Adipokines protecting CKD.

Increasing incidence of chronic kidney disease (CKD) which leads to end-stage renal disease (ESRD) is one of the major health issues in the modern world and requires novel strategies for treatment. Adipose tissue has been recognized to have endocrine function and secretes a variety of hormones called adipokines. Several adipokines have been implicated in the pathogenesis of CKD and may have a s...

A randomized trial of sodium-restriction on kidney function, fluid volume and adipokines in CKD patients

BACKGROUND Dietary sodium restriction is a key management strategy in chronic kidney disease (CKD). Recent evidence has demonstrated short-term reduction in blood pressure (BP) and proteinuria with sodium restriction, however the effect on other cardiovascular-related risk factors requires investigation in CKD. METHODS The LowSALT CKD study involved 20 hypertensive Stage III-IV CKD patients c...

Ckd-mineral and Bone Disorders (ckd-mbd)

Adipokines in pancreatic diseases

Recently, because of the growing number of obese people, the correlation between adipose tissue and numerous disorders has drawn the attention of researchers. The products of adipose tissue, adipokines: leptin, adiponectin, visfatin and resistin, affect lipid metabolism, insulin secretion and inflammatory response. Therefore, it is possible that adipokines take part in the pathogenesis of acute...

Adipokines and aging.

Dysregulation of adipose tissue-derived bioactive molecules, termed adipokines, is recognized as common ground for insulin resistance and metabolic syndrome associated with obesity. However, adipokine dysregulation is paradoxically associated with lipodystrophy and lipoatrophy with aging. In familial partial lipodystrophic syndromes and Hutchinson-Gilford progeria syndrome, both of which are ca...